A research team from the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences has developed an acoustic trapping chip that can provide three-dimensional (3D) trapping of cells in a continuously flowing medium with a circular resonance structure.
The study, titled “Acoustic 3D trapping of microparticles in flowing liquid using circular cavity,” has been published in Sensors and Actuators A: Physical.
Cell trapping is of great importance in biomedical engineering because it enables the clamping, separation, filtration and agglomeration of cells. Among different trapping approaches, acoustic trapping has been widely used in biological research because it can provide contactless and biosafe cell manipulation.
Ultrasonic standing waves can be further categorized into standing bulk acoustic waves (BAW), generated by a bulk piezoelectric transducer, or standing surface acoustic waves (SAW), generated by single crystal lithium niobate (LiNbO3) etched with interdigitated electrodes. SAW can manipulate particles with very low energy consumption, but it is generally used for sorting in flowing liquid and particle arrangement in stationary liquid due to its overall smaller clamping force compared with BAW.
On the other hand, the acoustic microstreaming vortex can also be applied to trap cells near the obstacle or microbubbles. The design of micropillars or obstacles plays an important role in improving the trapping efficiency. However, some of the traps cannot release particles easily, and some of them cannot provide a fixed trapping position.
The trapping efficiency is basically determined by the trapping force. In most previous studies, particles are usually trapped in a static fluid or a fluid flowing at extremely low speed, or the trapping process takes several seconds, which is mainly due to insufficient trapping force. This reduces both trapping efficiency and throughput, while high-throughput cell manipulation is important in many biological applications, such as Raman identification and nanoparticle capture.
The researchers established a standing acoustic wave in the circular microstructure, providing sufficient force to clamp cells in the center of the chamber. Meanwhile, cells near the bottom of the micro channel are clamped under the radiation force generated in the depth direction.
Thus, a 3D cell confinement is formed with a special design of microchannels actuated by only one piezoelectric plate transducer. Experimental results show that the chip can provide nanonewton (nN) level trapping force and millisecond (ms) level trapping time for micron-sized particles moving at the speed of mm/s level.
With this non-contact and biocompatible trapping method, the chip can be applied to a variety of biomedical engineering scenarios such as organ chips, cell culture, Raman analysis and nanoparticle capture.
Ce Wang et al, Acoustic 3D trapping of microparticles in flowing liquid using circular cavity, Sensors and Actuators A: Physical (2023). DOI: 10.1016/j.sna.2023.114698
Chinese Academy of Sciences
Scientists develop acoustic 3D trapping of microparticles in flowing liquid using circular cavity (2023, October 11)
retrieved 11 October 2023
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
myths of moonrise mod 1 18 1 unlimited money gems latest
kahoot generator bots understudies can as of now send crawlers to
evony the king s return mod apk v4 40 0 unlimited money 2023
why can t i watch videos for extra rolls dice dreams
project makeover mod apk v2 50 1 unlimited money apkloo
free real beach buggy racing gold gems hack and cheats for
TikTok Coin Farming: Tips for Success
Impulsa tu Cuenta de TikTok con Monedas Gratis
Get Free Spins Today: Coin Master Tips and Tricks
Free Avacoins in Avakin Life: Insider Secrets
Bingo Blitz Credits Hack for Bingo Enthusiasts
The Power of Spins in Coin Master: Explained
genshin impact codes for january 2023 rock paper shotgun
A Deep Dive into ZEPETO Zems Generation
match masters free gifts coins and boosters pocket tactics
The Secret Sauce to TikTok Coin Generation
Brawl Stars Gems Generator Review: Best Practices
free dragon city gems generator 2023 no human verification free
how to free rubies family island game 2023 youtube
hay day h k cheats free diamonds bots the truth
litmatch mod apk 6 3 2 0 unlimited diamonds unlocked vip
cheat codes myths of moonrise for android and ios
5 blooket hacks for 2023 updated add tokens unlock all blooks
evony the kings return hack mod wattpad
dice dream free rolls flowpage flowcode