February 28, 2024
An innovative method to revolutionize the understanding of disease and immune evasion mechanisms
Graphical Abstract. Credit: Cell Host & Microbe (2023). DOI: 10.1016/j.chom.2023.09.003

Toxoplasma infects a large part of the human population and animals. While most infections are harmless, the parasite poses a severe threat to the immunocompromised and during pregnancy. Toxoplasma is predicted to secrete over 200 proteins into the host cell, and most of these proteins’ functions are unknown.

A recent study, published in the journal Cell Host & Microbe, allows researchers to describe a function for each protein in changing host cell transcription in in a single experiment. Applying the new method, Dual Perturb-Seq, to Toxoplasma gondii, the research team identified and characterized novel effector proteins secreted by the parasite into the human host cells to change their behavior.

One of the major findings of this study is the identification of an effector, TgSOS1, which is required for changing a key host immune signaling pathway. This discovery highlights the parasite’s pivotal role in reprograming transcription during infection and establishing persistent infection.

Moritz Treeck, corresponding author of the paper, expressed enthusiasm about the study’s potential impact. “The dual perturb-see method not only provides a deeper understanding of host-microbe transcriptional interactions but also offers a versatile tool for investigating a wide range of pathogens. This breakthrough brings us one step closer to unraveling the complexities of infection and developing more effective strategies to combat .”

In the following steps, the research team will expand the experiments to cells of other species to understand how the parasite can infect any warm-blooded animal and make it one of the most successful on Earth.

More information:
Simon Butterworth et al, High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription, Cell Host & Microbe (2023). DOI: 10.1016/j.chom.2023.09.003

Provided by
Instituto Gulbenkian de Ciência

Novel method for high-throughput identification of T. gondii effector proteins that target host cell transcription (2023, October 11)
retrieved 11 October 2023
from https://phys.org/news/2023-10-method-high-throughput-identification-gondii-effector.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

match masters arena 7 funny game like paper clash royale what
Free TikTok Coins: Your Path to Fame
Free Gems in Brawl Stars: Your Path to Victory
easy working free dragon city gems generator
how to cheat on family island nteh itzehoe de
hay day hack get free coins and diamonds no human verification
litmatch mod apk v4 5 0 0 unlimited diamond free vip
myths of moonrise codes gameskeys net
download pull the pin 152 0 1 mod unlimited money i1apk
switch controllers are getting google chrome support artictle
dice dreams unlimited free rolls hack 2022 cakeresume
project makeover mod apk 2 56 1 unlimited money happymod
download beach buggy racing 2023 01 11 apk mod free 5play
Free Coins on TikTok: Tips and Tricks
Generatori di Monete TikTok: Ne Vale la Pena?
Coin Master Free Spins Myths and Facts: Unraveled
The Future of Avacoins in Avakin Life: Trends and Predictions
The Art of Earning Credits in Bingo Blitz
Unlimited Spins in Coin Master: Myth or Reality?
genshin impact codes free primogems and items metro uk
Mastering ZEPETO Zems: Expert Insights
coin master liens des tours spins et coins gratuits gamewave
Legit Ways to Get TikTok Coins for Free
Boost Your Brawl Stars Progress with Free Gems
pdf hack genera tor 2022 hack no human survey 6r8f 8y

Leave a Reply

Your email address will not be published. Required fields are marked *