February 28, 2024
MoMFs could be central to liver regeneration
Monocyte-derived macrophages (MoMFs) (cyan) encapsulate the necrotic areas and promote the expression of SOX9 (red) in hepatocytes (HNF4α; green) adjacent to MoMFs. Endothelial cells (CD31; blue) and the membrane of hepatocytes (β-catenin; magenta) are also shown. Credit: By Dr. Dechun Feng

The liver is a vital organ that plays a role in many essential functions, including digestion, detoxification, and metabolism. When the liver is damaged, it has the remarkable ability to regenerate itself. However, the process of liver regeneration is not fully understood.

A critical aspect of liver regeneration is removing dead tissue and necrotic lesions. In a recent study published in the Journal of Clinical Investigation, Feng et al. showed that monocyte-derived macrophages (MoMFs) play a crucial role in this process. MoMFs are a type of white blood cell that is recruited to the liver in response to injury. Once in the liver, MoMFs engulf dead cells and other debris. They also release chemicals that promote the healing process.

The researchers found that MoMFs undergo dynamic changes as they work to remove necrotic lesions. In the early stages of liver regeneration, MoMFs are pro-inflammatory. This means that they release chemicals that kill bacteria and other harmful invaders. However, in the later stages of liver regeneration, MoMFs become anti-inflammatory. This means that they release chemicals that promote healing and tissue repair.

The researchers also found that MoMFs interact with other cells in the liver to help remove necrotic lesions. For example, MoMFs interact with hepatocytes () to help them regenerate. MoMFs also interact with stellate cells (liver that produce collagen) to help them form a scar around the necrotic lesion.

The authors also found that similar mechanisms are involved in the resolution of necrosis in other models of liver injury, such as Klebsiella pneumoniae infection and ischemia/reperfusion. However, a different mechanism is likely in place in hepatotoxin/drug-induced liver injury models, such as carbon tetrachloride and acetaminophen.

The findings of this study suggest that macrophage-based immunotherapy approaches targeting hepatic necrosis could be a promising new treatment strategy for various liver diseases. For example, autologous macrophage therapy for fibrosis is already being investigated.

Clinical trials are needed to evaluate the safety and efficacy of macrophage-based immunotherapy approaches for treating hepatic necrosis. However, the findings of this study provide a strong foundation for developing these new therapies.

More information:
Dechun Feng et al, Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models, Journal of Clinical Investigation (2023). DOI: 10.1172/JCI166954

Provided by
First Hospital of Jilin University

Monocyte-derived macrophages could be central to liver regeneration (2023, September 29)
retrieved 29 September 2023
from https://phys.org/news/2023-09-monocyte-derived-macrophages-central-liver-regeneration.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

How to Get Avacoins in Avakin Life Legally and Quickly
Free Credits in Bingo Blitz: Where to Find Them
Earn Free Spins in Coin Master Like a Pro
genshin impact 2 1 codes list september free primogem codes
ZEPETO Zems Hack: Elevate Your ZEPETO Experience
match master mod unlimited coins 2023 android ios youtube
TikTok Coin Farming: Tips for Success
Brawl Stars Gems Hack for Brawl Enthusiasts
real hack dragon city gems 99999 2023 no verification sh9d
pdf hack family island cheats gift codes family island free hack
free hay day diamonds coins tricks apk android app تنزيل
litmatch mod apk 6 4 1 0 unlimited diamond vip no ads 2022
myths of moonrise codes wiki 2022 september theclashify
recovery phrase generator desk x 3 your yhpokerstore
evony the kings return hack unlimited gems generator nifty gateway
dice dreams hack free cheats on android ios 2023 novagames
project makeover mod get free gems hack generator ios
beach buggy racing 1 2 25 apk mod coins gems for android
The Future of TikTok Coins: Trends and Predictions
Wie Sie Kostenlose TikTok-Münzen Erhalten: Bewährte Strategien
Coin Master Free Spins Hack: A Complete Overview
Avakin Life Avacoins Hack: Boost Your Virtual Wealth for Free
Boost Your Bingo Blitz Gameplay with Free Credits
Free Spins in Coin Master: Elevating Your Gaming Experience
genshin impact 3 4 every livestream code reward screen rant

Leave a Reply

Your email address will not be published. Required fields are marked *